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Retroperitoneal malignant peripheral nerve sheath tumor: evaluation with serial FDG-PET
Subhash Chander1, Steven M Westphal, Imad T Zak
1Department of Radiology, Wayne State University/Detroit Medical Center, Detroit, Michigan,USA. chandler@pol.net
Abstract:
Retroperitoneal malignant peripheral nerve sheath tumor (MPNST), a rare type of neurogenic tumor, was diagnosed in a 14-year-old girl with a history of neurofibromatosis type 1 (NF1). Immunochemistry demonstrated spindle cells positive for S-100 protein. The patient had multiple tumor recurrences and she was evaluated with serial F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). A tumor in the right iliac wing showed increased FDG uptake on PET. FDG-PET played an important role in therapy planning and subsequent follow up. This case emphasizes the important role FDG-PET could play in the staging, restaging, and posttherapy follow up of MPNST.