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Gene Editing of Primary Rhesus Macaque B Cells
Published on: February 10, 2023
Enhancement of DNA vaccine potency in rhesus macaques by electroporation
Gillis Otten1, Mary Schaefer, Barbara Doe
1Vaccines Research, Chiron Corporation, 4560 Horton St., Mail Stop 4-3, Emeryville, CA 94068, USA.
Vaccine
|June 15, 2004
Abstract:
The potency of an HIV DNA vaccine was enhanced in rhesus macaques by in vivo electroporation, as judged by increased onset, magnitude and duration of antibody and cell-mediated immune responses against both components of a combination Gag and Env vaccine. These data demonstrate the utility of the electroporation technology for use in large animals.
