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Related Experiment Videos

Corepressor requirement and thyroid hormone receptor function during Xenopus development.

Laurent M Sachs1

  • 1Département Régulations, Développement et Diversité Moléculaire, USM 501 Muséum National d'Histoire Naturelle, UMR-5166 CNRS, 75231 Paris cedex 05, France.

Vitamins and Hormones
|June 15, 2004
PubMed
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Thyroid hormone receptor (TR) action during amphibian metamorphosis involves both gene activation and repression. Unliganded TRs repress genes for larval development, while liganded TRs activate genes for transformation.

Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Biology

Background:

  • Hormonal regulation of nuclear receptors is crucial for development.
  • The role of gene repression in biological processes is increasingly recognized.
  • Amphibian metamorphosis is a thyroid hormone-dependent process involving significant gene regulation.

Purpose of the Study:

  • To investigate the dual role of thyroid hormone receptor (TR) in regulating gene expression during amphibian development.
  • To elucidate the significance of gene repression mediated by unliganded TRs.
  • To understand the function of corepressors in thyroid hormone receptor action.

Main Methods:

  • Analysis of gene regulation by thyroid hormone receptor (TR) during different developmental stages.

Related Experiment Videos

  • Investigation of corepressor and coactivator complex recruitment by TR.
  • Studying the effects of 3,5,3'-triiodothyronine (T(3)) on gene expression.

    • Main Results:

    • Unliganded TRs repress gene expression via corepressor recruitment, essential for larval development.
    • Liganded TRs activate gene expression through coactivator recruitment, driving metamorphosis.
    • Evidence suggests a role for corepressors even during metamorphosis, potentially involving TRs.

    Conclusions:

    • Thyroid hormone receptors (TRs) exhibit a dual function in amphibian development, mediating both gene repression and activation.
    • Gene repression by unliganded TRs is critical for larval growth and metamorphic competence.
    • The study highlights the significant biologic role of corepressors in regulating gene expression during development.