Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A quantitative morphometric study of the human anterior cingulate cortex.

Rebecca Gittins1, Paul J Harrison

  • 1Department of Psychiatry, University of Oxford, Neurosciences Building, Warneford Hospital, OX3 7JX, Oxford, UK.

Brain Research
|June 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Reply to: Methodological Issues in Taquet et al.'s analysis preclude any conclusions regarding AS01 adjuvant's specific role in dementia prevention.

NPJ vaccines·2025
Same author

Lower risk of dementia with AS01-adjuvanted vaccination against shingles and respiratory syncytial virus infections.

NPJ vaccines·2025
Same author

Can liaison neurology add value to patient care within a mental health setting?

The British journal of psychiatry : the journal of mental science·2025
Same author

Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment.

Molecular psychiatry·2025
Same author

12-month neurological and psychiatric outcomes of semaglutide use for type 2 diabetes: a propensity-score matched cohort study.

EClinicalMedicine·2025
Same journal

IGFBP3 and UBE2C are associated with protein modification pathways and serve as prognostic markers in glioma.

Brain research·2026
Same journal

Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

Brain research·2026
Same journal

Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

Brain research·2026
Same journal

Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

Brain research·2026
Same journal

Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

Brain research·2026
Same journal

Emotions, the amygdala, and the right hemisphere.

Brain research·2026
See all related articles

The anterior cingulate cortex (ACC) shows significant structural differences between its supragenual and subgenual regions. These variations in neuronal size and density are crucial for interpreting morphometric studies in psychiatric disorders.

Area of Science:

  • Neuroscience
  • Neuroanatomy
  • Psychiatric Research

Background:

  • Morphometric changes in the anterior cingulate cortex (ACC) are implicated in schizophrenia and mood disorders.
  • Previous research suggests preferential involvement of the left subgenual ACC, but quantitative data on ACC cytoarchitecture is limited.

Purpose of the Study:

  • To quantitatively assess morphometric differences across five anatomical levels of the human ACC in normal brains.
  • To compare supragenual and subgenual ACC regions regarding cortical and layer depths, neuronal density, size, and glial density.

Main Methods:

  • Quantitative morphometric analysis of five ACC anatomical levels (subgenual and supragenual) in five normal human brains.
  • Utilized the optical disector and nucleator techniques to measure cortical depth, layer depths, neuronal density, neuronal size, and glial density.

Related Experiment Videos

Main Results:

  • Supragenual ACC exhibited greater thickness and a deeper layer V compared to subgenual ACC.
  • Neurons in supragenual ACC were larger and less densely packed in layers V and VI than in subgenual ACC.
  • Higher glial density and glia-to-neuron ratio were observed in supragenual ACC.

Conclusions:

  • Significant cytoarchitectural heterogeneity exists within the human ACC, particularly between supragenual and subgenual regions.
  • Normal anatomical variations in the ACC are substantial and must be considered in morphometric studies of psychiatric disorders to avoid misinterpretation.