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Impaired left ventricular diastolic function during isometric exercise in asymptomatic patients with hyperlipidaemia
Abdul-Majeed Salmasi1, Peter Frost, Mark Dancy
1Cardiac Research Unit, Cardiology Department, The Central Middlesex Hospital, Acton Lane, London NW10 7NS, UK. majeed.salmasi@nwlh.nhs.uk
International Journal of Cardiology
|June 15, 2004
Summary
Asymptomatic hyperlipidemia patients show early signs of heart issues. Left ventricular diastolic dysfunction appears even with normal stress tests, suggesting pre-clinical ischemia.
Area of Science:
- Cardiology
- Cardiovascular Physiology
- Diagnostic Imaging
Background:
- Left ventricular (LV) diastolic dysfunction is an early indicator of ischemic heart disease (IHD).
- Diastolic dysfunction may be a more sensitive marker of IHD than systolic dysfunction.
Purpose of the Study:
- To assess LV diastolic function during isometric exercise (IME) in asymptomatic hyperlipidemic patients.
- To compare LV diastolic function between hyperlipidemic individuals and healthy controls.
Main Methods:
- Echocardiography and Doppler were used to evaluate LV diastolic function at rest and during IME in 37 hyperlipidemic patients and 37 controls.
- Key parameters measured included E/A ratio, atrial contraction fraction (ACF), deceleration time (DT), and isovolumic relaxation time (IVRT).
Main Results:
- Hyperlipidemic patients showed a significant reduction in E/A ratio during IME, indicating impaired LV filling.
- 54% of hyperlipidemic patients exhibited diastolic dysfunction at peak IME, compared to none in the control group.
- LV diastolic dysfunction was present in 15 patients with negative stress ECG tests.
Conclusions:
- A significant prevalence of LV diastolic dysfunction exists in asymptomatic hyperlipidemic patients.
- This dysfunction, even with a negative stress ECG, may indicate early, pre-clinical myocardial ischemia.
- LV diastolic function assessment during IME is valuable for detecting early cardiac changes in hyperlipidemia.