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Oxidative stress in neonates: evaluation using specific biomarkers.
Hirokazu Tsukahara1, Mi-Zu Jiang, Naoko Ohta
1Department of Pediatrics, Fukui Medical University, Fukui 910-1193, Japan. htsuka@fmsrsa.fukui-med.ac.jp
Life Sciences
|June 15, 2004
Summary
Sick preterm neonates exhibit elevated oxidative stress markers, including DNA and protein damage. This indicates increased oxidative damage, particularly in clinically ill preterm infants, impacting their health outcomes.
Area of Science:
- Neonatal Medicine
- Biochemistry
- Oxidative Stress Research
Background:
- Oxidative stress is linked to severe neonatal diseases.
- Biomarkers are needed to assess oxidative stress in neonates.
Purpose of the Study:
- To measure oxidative stress markers in neonates.
- To correlate oxidative stress with prematurity and clinical status.
Main Methods:
- Measured urinary 8-hydroxy-2'-deoxyguanosine, acrolein-lysine adduct, and nitrite/nitrate.
- Compared levels in healthy term, stable preterm, and sick preterm neonates.
Main Results:
- Sick preterm neonates had higher urinary 8-hydroxy-2'-deoxyguanosine and acrolein-lysine adduct.
- Higher acrolein-lysine adduct levels were found in sick preterm neonates with retinopathy.
- No significant differences in oxidative stress markers between stable preterm and healthy term neonates.
Conclusions:
- Clinically sick preterm neonates show augmented oxidative damage to DNA, lipids, and proteins.
- Oxidative stress is a significant factor in the pathogenesis of diseases in sick preterm infants.