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Impact of erythropoietic activity on red cell parameters in chronic renal failure patients

Christophe Bovy, Jean-Marie Krzesinski, André Gothot

    Haematologica
    |June 15, 2004
    PubMed

    We measured red cell parameters during recombinant human erythropoietin (rHuEPO) therapy associated with appropriate iron supplementation in chronic hemodialysis patients. Increased erythropoietic activity led to a bias in red cell parameter determination. The percentage of hypochromic red blood cells, usually used as the most effective predictor of response to iron supplementation, increased following the appearance of a younger red cell population since the same Hb content in these younger, larger cells gives a lower Hb concentration.

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