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Related Experiment Videos

Slowly progressive limb-kinetic apraxia with a decrease in unilateral cerebral blood flow.

B Okuda1, H Tachibana, K Kawabata

  • 1Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.

Acta Neurologica Scandinavica
|July 1, 1992
PubMed
Summary
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Two patients with slowly progressive motor disorders showed asymmetric limb-kinetic apraxia and rigidity. Single photon emission computed tomography (SPECT) revealed decreased cerebral blood flow (CBF) in unilateral hemispheres, suggesting cortico-basal degeneration.

Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Investigating slowly progressive motor disorders characterized by limb-kinetic apraxia and muscle rigidity.
  • Exploring the utility of neuroimaging techniques in diagnosing atypical neurological conditions.

Observation:

  • Two patients presented with asymmetric limb-kinetic apraxia and muscle rigidity.
  • Magnetic resonance imaging (MRI) did not reveal any causative lesions in either patient.
  • Single photon emission computed tomography (SPECT) demonstrated reduced cerebral blood flow (CBF) in unilateral cerebral hemispheres.

Findings:

  • Patient 1: Right-sided apraxia correlated with decreased left hemisphere CBF in frontoparietal regions.
  • Patient 2: Left-sided apraxia correlated with decreased right hemisphere CBF in the parietal cortex.

Related Experiment Videos

  • Asymmetric clinical symptoms corresponded with unilateral regional CBF reductions.

    • Implications:

    • These findings suggest a potential degenerative etiology, possibly cortico-basal degeneration.
    • SPECT imaging may aid in identifying functional deficits in neurodegenerative diseases.
    • Understanding the relationship between regional CBF and specific motor deficits is crucial for diagnosis.