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Updated: Aug 12, 2026

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
Published on: June 17, 2013
A dissociation between real and simulated movements in Parkinson's disease
Victor Frak1, Henri Cohen, Emmanuelle Pourcher
1Cognitive Neuroscience Center, Université du Québec à Montréal, PB. 8888, Stn. Centre-Ville, Montreal, Qc. H3C 3P8, Canada. frak.victor@uqam.ca
Abstract:
Subcortical lesions have been simultaneously implicated in both real and simulated movement deficits. However, the analysis of the simulated opposition axis in precision grasping reveals that, in individuals with idiopathic bilateral Parkinson' disease motor imagery is impaired and that execution of overt movements is spared. This constitutes the first lesion observation congruent with the anatomical and functional dichotomy between real and simulated movements seen in experimental studies. These results underline the modality-specific nature of motor imagery and show that subcortical damage differentially impacts on motor activity.
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