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[Clinicopathological and immunohistochemical study of malignant lymphoma of the orbit]
T Sakamoto1, T Ishibashi, Y Ohnishi
1Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
The authors performed histopathological and immunohistochemical studies of 14 cases of orbital malignant lymphoma except for the conjunctival one. The patients were composed of 9 males and 5 females, and the average age of the cases was 61.5 +/- 12.3 years old. All cases were unilateral malignant lymphomas, 5 cases were right and 9 cases were left. Two patients had stage I disease, 10 patients had stage II disease, and 2 patients had stage III disease. The 5 year-survival rate was in 7/12 (58%). Histopathological examination revealed that 3 cases belonged to small lymphocytic, 4 cases diffuse small cleaved, 3 cases diffuse mixed and 4 cases diffuse large cell type by the working formulation. Immunohistochemical examination showed that all cases reacted positively against the B cell markers, while negatively against the T cell markers except for 1 case, indicating the cases were B cell lymphomas. Additionally, an immunoglobulin study contributed to elucidate the monoclonal proliferation of the tumor cells.
The authors performed histopathological and immunohistochemical studies of 14 cases of orbital malignant lymphoma except for the conjunctival one. The patients were composed of 9 males and 5 females, and the average age of the cases was 61.5 +/- 12.3 years old. All cases were unilateral malignant lymphomas, 5 cases were right and 9 cases were left. Two patients had stage I disease, 10 patients had stage II disease, and 2 patients had stage III disease. The 5 year-survival rate was in 7/12 (58%). Histopathological examination revealed that 3 cases belonged to small lymphocytic, 4 cases diffuse small cleaved, 3 cases diffuse mixed and 4 cases diffuse large cell type by the working formulation. Immunohistochemical examination showed that all cases reacted positively against the B cell markers, while negatively against the T cell markers except for 1 case, indicating the cases were B cell lymphomas. Additionally, an immunoglobulin study contributed to elucidate the monoclonal proliferation of the tumor cells.