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[Updated reference intervals for clinical chemical components].

Petter Urdal1, Bjørn Bolann, Sverre Marstein

  • 1Klinisk kjemisk avdeling, Ullevål universitetssykehus, 0407 Oslo. petter.urdal@ulleval.no

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|June 15, 2004
PubMed
Summary

The Nordic reference interval project (NORIP) established updated, common reference intervals for 25 clinical biochemical components across Nordic countries. These new intervals, including age and sex-specific data, aim to replace outdated standards in laboratory diagnostics.

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Area of Science:

  • Clinical Biochemistry
  • Laboratory Medicine
  • Reference Interval Standardization

Context:

  • Outdated reference intervals are prevalent in clinical biochemistry.
  • Need for updated, harmonized reference intervals across Nordic countries.
  • The Nordic Reference Interval Project (NORIP) was initiated to address this gap.

Purpose:

  • To establish common, updated reference intervals for 25 clinical biochemical components.
  • To provide age- and sex-specific reference intervals where statistically appropriate.
  • To facilitate the adoption of standardized laboratory diagnostic criteria in the Nordic region.

Summary:

  • NORIP involved 102 Nordic laboratories and 3036 participants aged 18+.
  • Measurements were performed for 25 serum and/or plasma components.

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  • Common reference intervals were calculated, with specific considerations for age and sex.

    • Impact:

    • National clinical biochemical societies in Norway, Sweden, Finland, and Denmark recommend adoption.
    • Implementation of new enzyme reference intervals in Norway began in 2003/2004.
    • Minimal impact on medical decision limits due to unchanged measuring methods for most components.