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Updated: Aug 23, 2026
Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
Published on: February 9, 2020
[The relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma]
Zhi-jian Xie1, Xiao-feng Yang, Jun Fan
1Department of Oral and Maxillofacial Surgery, The Affiliated Stomatological Hospital, College of Medical Science, Zhejiang University, Hangzhou 310006, China. xzj66@zju.edu.cn
Objective:
To probe the relationship between lymphangiogenesis and cervical lymph node micrometastasis in oral squamous cell carcinoma.
Methods:
The microlymphatic vessel density was detected with enzyme histo-chemical method in 47 cases of oral squamous cell carcinoma and 10 cases of normal oral mucosa; 355 lymphnodes were detected with immunohistochemically using monoantibody AE3.
Results:
The mean MLVD was 14.04 +/- 6.92 in tumor group, or 5.48 +/- 2.62 in normal group. The difference was (P < 0.001). The percentage of tumor with expression CK was 48.9%. The mean MLVD was 16.94 +/- 5.43 in CK positive group, or 11.26 +/- 5.00 in CK negative group, There was difference significant (P < 0.001).
Conclusions:
Lymphangiogenesis plays a key role in cervical lymph node micrometastasis of oral squamous cell carcinoma.
