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Related Experiment Videos

GnRH antagonists.

Maria Elisabetta Coccia1, Ciro Comparetto, Gian Luca Bracco

  • 1Department of Gynaecology, Perinatology, and Human Reproduction, University of Florence, Via Ippolito Nievo 2, 50129 Florence, Italy. cocciame@tin.it

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|June 16, 2004
PubMed
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Gonadotropin-releasing hormone antagonists (GnRH-ant) offer an effective alternative for ovarian stimulation in in vitro fertilization (IVF), potentially reducing gonadotropin dosage and OHSS risk.

Area of Science:

  • Reproductive Endocrinology
  • Assisted Reproductive Technology

Background:

  • Ovarian stimulation is crucial for in vitro fertilization (IVF) success, aiming for multiple oocytes and embryos.
  • Gonadotropin-releasing hormone antagonists (GnRH-ant) combined with gonadotrophins provide an alternative to GnRH agonist protocols.

Purpose of the Study:

  • To review the applications of GnRH-antagonists in assisted reproduction technology (ART) cycles.
  • To evaluate the efficacy and safety of GnRH-antagonist protocols compared to traditional methods.

Main Methods:

  • Review of literature on GnRH-antagonist applications in ART.
  • Analysis of two distinct GnRH-antagonist protocols: multiple-dose and single-dose.

Main Results:

  • GnRH-antagonist protocols are simple, efficacious, and initiated in the late follicular phase.

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  • Literature suggests smaller gonadotropin doses, shorter stimulation, and lower OHSS incidence with GnRH-antagonists versus agonists.
  • Potential indications include ovulation triggering, PCOS, and poor responder patients.

    • Conclusions:

    • GnRH-antagonists represent a valid and effective option for ovarian stimulation in ART.
    • Further data is required on pregnancy rates and potential adverse effects on endometrium or implantation.