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Intramuscular tramadol increases gastric pH during anesthesia
Kouichiro Minami1, Junichi Ogata, Takafumi Horishita
1Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu, Japan. kminami@med.uoeh-u.ac.jp
Summary
Tramadol, an analgesic, was found to increase gastric pH during anesthesia, similar to famotidine. This suggests tramadol effectively inhibits gastric acid secretion in surgical patients.
Area of Science:
- Anesthesiology
- Pharmacology
- Gastroenterology
Background:
- Tramadol is a widely used analgesic.
- Tramadol is known to inhibit muscarinic type 3 receptors, which are involved in gastric secretion.
- The effect of tramadol on gastric acid secretion during anesthesia requires further investigation.
Purpose of the Study:
- To investigate the effect of tramadol on gastric juice pH during general anesthesia.
- To determine if tramadol inhibits gastric acid secretion from gastric glands.
Main Methods:
- A randomized controlled trial involving 30 adult patients undergoing major elective surgery.
- Patients were assigned to receive tramadol, famotidine, or saline.
- Gastric pH was measured before anesthesia and three hours after drug administration.
Main Results:
- No significant differences in gastric pH were observed before anesthesia among the groups.
- Tramadol administration resulted in a significant increase in gastric pH, comparable to famotidine.
- The mean gastric pH in the tramadol group was 6.4 +/- 0.8, compared to 2.6 +/- 2.5 in the saline group.
Conclusions:
- Tramadol appears to inhibit gastric acid secretion.
- These findings suggest a potential role for tramadol in managing gastric acid levels during anesthesia.