Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening of alternative models for transitional B cell maturation.

Gitit Shahaf1, David Allman, Michael P Cancro

  • 1Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.

International Immunology
|June 16, 2004
PubMed
Summary

Mathematical modeling reveals that B cell differentiation in the spleen does not require proliferation. Some developing B cells bypass early splenic stages, moving directly from the marrow to semi-mature subsets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Female mice with a Xist deletion in B cells can develop lupus-associated phenotypes.

Cell reports·2026
Same author

The ancestral haplotype of P2RX5 yields a B-cell surface marker and a multi-lineage immunotherapy target.

bioRxiv : the preprint server for biology·2026
Same author

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.

bioRxiv : the preprint server for biology·2025
Same author

Normal Treg homeostasis and suppressive function require both FOXP1 and FOXP4.

JCI insight·2025
Same author

Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications.

Nature nanotechnology·2025

Area of Science:

  • Immunology
  • Computational Biology
  • Cellular Dynamics

Background:

  • B cell differentiation involves transitional subsets, but their exact relationships and the necessity of proliferation for follicular B cell maturation are debated.
  • The potential for branched or asynchronous B cell maturation pathways, allowing stage skipping, remains unexplored.

Purpose of the Study:

  • To investigate the progenitor-successor relationships of splenic B cell subsets using mathematical modeling.
  • To determine if a proliferative step is essential for follicular B cell maturation.
  • To explore alternative B cell differentiation pathways, including potential stage skipping.

Main Methods:

  • Development of mathematical models to simulate splenic B cell population dynamics.
  • Numerical simulation of B cell differentiation pathways.

Related Experiment Videos

  • Fitting alternative differentiation models to existing in vivo labeling data.

    • Main Results:

    • Follicular B cell differentiation in the spleen does not involve a proliferating intermediate stage.
    • Evidence suggests that some developing B cells can transition directly from the immature marrow pool to semi-mature peripheral subsets.
    • The study refutes models requiring a proliferative splenic intermediate for B cell maturation.

    Conclusions:

    • Splenic B cell differentiation is a non-proliferative process.
    • B cell maturation may involve direct progression from immature to semi-mature stages, bypassing certain transitional subsets.
    • Mathematical modeling provides critical insights into complex cellular differentiation dynamics.