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Related Experiment Videos

Aggressive basal cell carcinoma: presentation, pathogenesis, and management.

Hobart W Walling1, Scott W Fosko, Pedram A Geraminejad

  • 1Department of Dermatology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA. hobart-walling@uiowa.edu

Cancer Metastasis Reviews
|June 16, 2004
PubMed
Summary

Aggressive basal cell carcinoma (BCC) development may stem from intrinsic tumor biology or inadequate early management. Both factors likely contribute to the progression of this common skin cancer.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Basal cell carcinoma (BCC) is the most common skin cancer, typically slow-growing with a high cure rate.
  • However, some BCCs exhibit aggressive behavior, including deep invasion, recurrence, and metastasis.
  • Factors like tumor size, duration, histology, and perineural spread are potential indicators of aggressiveness.

Purpose of the Study:

  • To review the literature and determine the factors contributing to the aggressive phenotype of basal cell carcinoma.
  • To explore whether intrinsic biological properties or extrinsic management factors drive aggressive BCC behavior.

Main Methods:

  • Literature review of pertinent studies on basal cell carcinoma aggressiveness.
  • Analysis of postulated markers for aggressive BCC, including clinical and histological features.

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Main Results:

  • Several factors, such as tumor size, duration, histology, and perineural spread, have been associated with aggressive BCC.
  • The literature suggests a dual role for both intrinsic biological factors and extrinsic management factors in the development and progression of aggressive BCC.

Conclusions:

  • Aggressive basal cell carcinoma behavior is likely influenced by a combination of inherent tumor characteristics and the adequacy of early management.
  • Further research is needed to fully elucidate the interplay between biological and management factors in BCC progression.