Integrin signaling and lipid rafts
Related Experiment Video
Updated: Aug 23, 2026

Lipid Exchange Assay in Living Cells
Published on: March 21, 2025
1Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain. madelpozo@cnic.es
Abstract:
Integrin-mediated adhesion regulates the recruitment of the small GTPase Rac to the plasma membrane and subsequent activation of downstream signaling. We recently reported that Rac binds preferentially to cholesterol-rich membranes ("lipid rafts"), and integrins regulate Rac function by preventing the internalization of its binding sites within these domains. Regulation of lipid rafts by integrins may be important for the spatial control of cell migration and signaling pathways involved in anchorage-dependent cell growth.
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