Related Experiment Videos
Partial lesion of thalamic ventral intermediate nucleus after chronic high-frequency stimulation
Jasmine Henderson1, Michael Rodriguez, Dudley O'Sullivan
1Department of Pharmacology, University of Sydney, NSW, Australia. henderson@med.usyd.edu.au
Abstract:
A 73-year-old man with Parkinson's disease underwent thalamic stimulation for disabling tremor with excellent results only when stimulation on. Post-mortem neuropathology (7 years postoperatively) revealed 60% cell loss within 0.5 mm of the electrode tip. Tremor improvement was attributable to chronic stimulation, not microthalamotomy.