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Recurrent tendinitis after treatment with two different fluoroquinolones
Olaf Burkhardt1, Thomas Köhnlein, Thomas Pap
1Department of Pulmonary and Critical Care Medicine, University Otto-von-Guericke, Magdeburg, Germany. olaf.burkhardt@medizin.uni-magdeburg.de
Scandinavian Journal of Infectious Diseases
|June 17, 2004
Summary
Fluoroquinolone antibiotics, including moxifloxacin, can cause rare tendon problems like tendinitis and rupture. This class effect may be more common than previously thought, affecting multiple fluoroquinolones.
Area of Science:
- Pharmacology
- Orthopedics
- Infectious Diseases
Background:
- Fluoroquinolones are broad-spectrum antibiotics used for bacterial infections.
- Tendinopathies, including tendon rupture, are known rare adverse events associated with fluoroquinolone use.
- Older fluoroquinolones were primarily implicated, but recent data suggests increased incidence with levofloxacin.
Observation:
- This report details the first documented case of tendinitis following treatment with moxifloxacin.
- A case of recurrent tendinitis was observed after treatment with two different fluoroquinolones.
- These observations highlight a potential class-wide effect of fluoroquinolones on tendons.
Findings:
- Moxifloxacin, a fluoroquinolone, has been associated with tendinitis.
- Recurrent tendinitis can occur with sequential use of different fluoroquinolones.
- Tendinopathy appears to be a class effect of fluoroquinolones.
Implications:
- The findings suggest tendinopathy is a class effect of fluoroquinolones, not limited to older agents or specific drugs.
- Clinicians should be aware of the risk of tendinitis and tendon rupture with moxifloxacin and other fluoroquinolones.
- Further investigation is warranted to understand the mechanism and prevalence of this fluoroquinolone-induced adverse event.