Related Experiment Video

Updated: Jul 29, 2026

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
07:26

Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel

Published on: June 29, 2015

Inherited prothrombotic defects in Budd-Chiari syndrome and portal vein thrombosis: a study from North India

Maitreyee Bhattacharyya1, Govind Makharia, M Kannan

  • 1Department of Hematology, All India Institute of Medical Sciences, New Delhi.

American Journal of Clinical Pathology
|June 17, 2004
PubMed

Insights

Inherited prothrombotic defects are common in Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). Factor V Leiden mutation was most frequent in BCS, while protein C deficiency was most common in PVT patients.

Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT) are serious conditions often linked to thrombotic events.
  • Identifying underlying inherited prothrombotic defects is crucial for patient management and risk assessment.

Purpose of the Study:

  • To investigate the prevalence of inherited prothrombotic defects in patients diagnosed with BCS and PVT.
  • To compare the frequency of specific genetic mutations and deficiencies between BCS and PVT cohorts.

Main Methods:

  • Studied 57 BCS patients and 48 PVT patients for inherited prothrombotic defects.
  • Analyzed deficiencies in protein C, protein S, and antithrombin III.
  • Screened for genetic mutations: factor V Leiden, prothrombin gene 20210A, and methyltetrahydrofolate reductase (MTHFR) C677T in a subset of patients.

Main Results:

  • Inherited prothrombotic defects were found in 28% of BCS patients and 15% of PVT patients.
  • Factor V Leiden mutation was the most common defect in BCS (17%), while protein C deficiency was most prevalent in PVT (8%).
  • Heterozygous MTHFR C677T mutation was observed in 24% of BCS and 21% of PVT patients.

Conclusions:

  • Inherited prothrombotic defects represent a significant risk factor in both BCS and PVT.
  • The etiological profile of these defects differs between BCS and PVT, highlighting the need for tailored genetic screening.
  • Further research is warranted to elucidate the full spectrum of genetic predispositions in these thrombotic disorders.

More Related Videos

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation08:45

New Thrombectomy Technique for Total Portal Vein Thrombosis in Liver Transplantation

Published on: June 27, 2025

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis07:34

Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis

Published on: December 30, 2025

Related Concept Videos

Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Portal Hypertension01:22

Portal Hypertension

Portal hypertension is an increase in blood pressure within the portal venous system. Normally, this pressure is less than 5 mmHg. It is considered clinically significant when it rises above 10 mmHg. At this threshold, complications from altered blood flow and venous congestion emerge.EtiologyPortal hypertension arises from conditions that impede blood flow through the liver. The most common cause is cirrhosis, in which chronic liver injury leads to fibrotic scarring. This fibrosis narrows or...