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Related Experiment Videos

Closing the loop: the adicol experience.

Roman Hovorka1, Ludovic J Chassin, Malgorzata E Wilinska

  • 1Diabetes Modelling Group, Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom. r.hovorka@uk.avecho.com

Diabetes Technology & Therapeutics
|June 17, 2004
PubMed
Summary

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The Advanced Insulin Infusion using a Control Loop (ADICOL) project developed a wearable artificial pancreas for type 1 diabetes. This system demonstrated feasibility for semi-closed-loop glucose control in both fasting and fed states.

Area of Science:

  • Biomedical Engineering
  • Endocrinology
  • Diabetes Technology

Background:

  • Type 1 diabetes management requires continuous glucose monitoring and insulin delivery.
  • Existing treatments often lack automated control, necessitating frequent patient intervention.
  • The development of an artificial pancreas aims to improve glycemic control and reduce the burden of diabetes management.

Purpose of the Study:

  • To develop and evaluate a modular, extracorporeal artificial pancreas system for type 1 diabetes.
  • To design and test a glucose controller for semi-closed-loop glucose regulation.
  • To assess the feasibility of the system in both fasting and fed conditions.

Main Methods:

  • Development of a modular system including a subcutaneous glucose sensor, PocketPC, and insulin pump.

Related Experiment Videos

  • In silico testing environment for controller evaluation.
  • Incremental experimental evaluation of a model predictive glucose controller through feasibility and efficacy studies.

    • Main Results:

    • Successful development of a glucose controller for semi-closed-loop operation.
    • Demonstration of feasibility for glucose control during fasting and fed states.
    • Integration and testing of a wearable, modular artificial pancreas system.

    Conclusions:

    • The ADICOL project successfully demonstrated the feasibility of a semi-closed-loop artificial pancreas for type 1 diabetes.
    • The wearable, modular system offers a promising approach to automated glucose management.
    • Further development can lead to improved glycemic control and quality of life for individuals with type 1 diabetes.