Related Experiment Video
Updated: May 4, 2026
07:29
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
8.4K
Atherogenic lipoprotein particles in atherosclerosis
Rafael Carmena1, Patrick Duriez, Jean-Charles Fruchart
1Department of Endocrinology and Nutrition, Facultad de Medicina y Hospital Clínico Universitario, Valencia, Spain.
Circulation
|June 17, 2004
Summary
Low-density lipoprotein (LDL) cholesterol is key in atherosclerosis, but other lipid particles like small, dense LDL and lipoprotein(a) are also significant risk factors. Understanding these diverse lipoproteins may refine cardiovascular disease treatment strategies.
Area of Science:
- Cardiovascular Disease Research
- Lipid Metabolism and Atherosclerosis
Background:
- Low-density lipoprotein (LDL) cholesterol is a primary target for preventing coronary heart disease.
- Emerging research highlights the atherogenic potential of various lipoproteins beyond LDL.
Purpose of the Study:
- To explore the heterogeneity of LDL particles and the role of non-LDL lipids in atherosclerosis.
- To examine the atherogenicity of specific lipoprotein subfractions and their impact on cardiovascular risk.
Main Methods:
- Review of current research on LDL particle heterogeneity.
- Analysis of studies investigating the atherogenic properties of various lipoproteins and their components.
Main Results:
- Small, dense LDL particles and oxidized LDL are particularly atherogenic.
- Lipoproteins containing apolipoprotein B, including very-low-density lipoprotein and intermediate-density lipoprotein, promote atherosclerosis.
- High plasma triglycerides and lipoprotein(a) are identified as independent risk factors for coronary events.
Conclusions:
- Understanding the diverse roles of lipid particles and subfractions in atherosclerosis is crucial.
- This knowledge may lead to more personalized and effective treatment decisions for cardiovascular disease prevention.
Related Concept Videos
01:38Inflammation
46.6K
Overview
46.6K
01:31Lipid-derived Compounds in the Human Body
5.5K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
5.5K
01:26Coronary Artery Disease II: Pathophysiology
1.1K
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K
01:30Atherosclerosis I: Introduction
2.5K
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
2.5K
01:26Atherosclerosis III: Management
741
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
741
01:30Peripheral Artery Disease I: Introduction
659
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
659