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Related Experiment Videos

Rhes is involved in striatal function.

Daniela Spano1, Igor Branchi, Annamaria Rosica

  • 1Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy.

Molecular and Cellular Biology
|June 17, 2004
PubMed
Summary
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Thyroid hormones are crucial for central nervous system development. Disrupting the Rhes gene in mice led to behavioral changes, including increased anxiety and motor deficits, but no learning impairments.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Genetics

Background:

  • Thyroid hormones are essential for central nervous system (CNS) development and function.
  • Thyroid hormone deficiency in humans causes cretinism, characterized by severe mental deficiency.
  • Thyroid hormones regulate brain development and function by controlling target gene expression.

Purpose of the Study:

  • To investigate the in vivo role of the Rhes gene, predominantly expressed in the brain's striatal region.
  • To understand the consequences of Rhes gene disruption on mouse behavior and physiology.

Main Methods:

  • Disruption of the Rhes gene using homologous recombination in embryonic stem cells.
  • Generation of Rhes null mutant mice (Rhes(-/-)) homozygous for the mutation.

Related Experiment Videos

  • Behavioral and physiological assessments of Rhes(-/-) mice compared to wild-type controls.

    • Main Results:

    • Rhes(-/-) mice were viable but exhibited reduced body weight compared to wild-type littermates.
    • Rhes(-/-) mice displayed gender-dependent increases in anxiety levels.
    • A significant motor coordination deficit was observed in Rhes(-/-) mice, without affecting learning or memory.

    Conclusions:

    • The Rhes gene plays a specific role in regulating selected behavioral competencies within the CNS.
    • Rhes disruption impacts anxiety and motor control, highlighting its importance in specific neural functions.
    • These findings contribute to understanding the genetic underpinnings of brain function and behavior related to thyroid hormone signaling pathways.