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Mitral annular calcification is associated with osteoporosis in women

Vedat Davutoglu1, Mustafa Yilmaz, Serdar Soydinc

  • 1Department of Cardiology, School of Medicine, Sahinbey Medical Center, Gaziantep University Gaziantep, Turkey. vedatdavutoglu@hotmail.com

American Heart Journal
|June 17, 2004
PubMed
Abstract

Insights

Mitral annular calcification (MAC) is linked to osteoporosis in post-menopausal women. Bone mineral density (BMD) and age are key predictors of MAC, highlighting a connection between cardiovascular and bone health.

Area of Science:

  • Cardiology
  • Osteoporosis Research
  • Geriatric Medicine

Background:

  • Limited research explores the link between mitral annular calcification (MAC) and osteoporosis in post-menopausal women.
  • Previous studies have not investigated MAC's association with osteoporosis using dual-energy x-ray absorptiometry (DEXA) for bone resorption assessment.

Purpose of the Study:

  • To investigate the association between mitral annular calcification (MAC) and osteoporosis in women.
  • To determine if MAC is a predictor of osteoporosis in the female population.

Main Methods:

  • A prospective, observational study involving 340 women (mean age 56 years).
  • Participants underwent echocardiography for MAC assessment and DEXA scans for bone mineral density (BMD) T-scores.

Main Results:

  • Mitral annular calcification (MAC) was present in 217 women and absent in 123.
  • Women with MAC showed a significantly higher prevalence and severity of osteoporosis (55.5%) compared to controls (18.2%).
  • Multivariate analysis identified T-scores and age as significant predictors of MAC (OR 2.66 and 1.04, respectively).

Conclusions:

  • Mitral annular calcification (MAC) is significantly associated with osteoporosis in women.
  • Bone mineral density (BMD) T-scores and patient age are strong predictors of MAC.

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