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Impact of microarray technology in clinical oncology.
Elizabeth A Raetz1, Philip J Moos
1Division of Hematology-Oncology, Huntsman Cancer Institute, University of Utah School of Medicine, Primary Children's Medical Center, Salt Lake City, Utah, USA.
Cancer Investigation
|June 18, 2004
Summary
Genomic technologies aid cancer classification and relapse risk assessment. Gene expression profiling will advance personalized genomic medicine for patient diagnosis and treatment selection.
Area of Science:
- Genomic medicine
- Oncology
- Molecular pathology
Background:
- Genomic technologies are rapidly advancing.
- Microarray analysis has been applied to numerous malignancies.
- Reporter gene expression profiling can create molecular portraits of diseases.
Purpose of the Study:
- To review the utility of genomic technologies in oncology.
- To highlight the potential of gene expression profiling in personalized medicine.
Main Methods:
- Microarray examination of malignancies.
- Analysis of reporter gene expression levels.
- Identification of molecular portraits for disease classification.
Main Results:
- Genomic technologies augment oncological pathology and clinical presentation.
- Reporter gene groups identified through analysis methodologies.
- Molecular portraits generated for various diseases.
Conclusions:
- Validated gene expression assessments will contribute to personalized genomic medicine.
- Gene expression profiling aids in diagnosis and treatment selection.
- The field is dynamic, with ongoing developments.