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[Clinical study on treatment of mild cognitive impairment by modified wuzi yanzong granule]
Xue-mei Wang1, Hong Fu, Geng-xin Liu
1First Hospital, Peking University, Beijing 100034. wangxuemei64@sohu.com
Objective:
To observe the clinical efficacy and safety of modified Wuzi Yanzong Granule (MWYG) in treating mild cognitive impairment (MCI), and to explore its mechanism.
Methods:
Forty-four MCI patients were selected referring to the international recognized Peterson's criteria and randomly divided into two groups, the treated group treated with MWYG and the control group treated with Ginkgo leaf extraction, with the course of 3 months for both groups. Changes of memorial quotient (MQ), superoxide dismutase (SOD) activity, malondialdehyde (MDA) content, mitochondrial DNA (mtDNA) deletion rate and acetylcholinesterase (AchE) before and after treatment were observed.
Results:
After treatment, levels of MQ, serum SOD activity increased and serum MDA content, mtDNA deletion rate and AchE decreased in both groups (P < 0.01), but the difference between the two groups was insignificant. No adverse reaction was found in two groups.
Conclusion:
Both MWYG and Ginkgo leaf capsule can effectively improve the memorial function of patients with MCI, the therapeutic mechanism is possibly related with the actions in reducing AchE activity, improving free radical metabolism, and alleviating mitochondrial DNA oxidation damage.
Insights
Modified Wuzi Yanzong Granule (MWYG) effectively improved memory in mild cognitive impairment (MCI) patients, similar to Ginkgo leaf extract. The treatment potentially works by reducing acetylcholinesterase activity and oxidative stress.
Area of Science:
- Neuroscience
- Pharmacology
- Gerontology
Background:
- Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia.
- Identifying effective treatments for MCI is crucial for preventing progression to Alzheimer's disease.
- Traditional Chinese Medicine offers potential therapeutic avenues for cognitive disorders.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of modified Wuzi Yanzanzong Granule (MWYG) in treating MCI.
- To investigate the underlying mechanisms of MWYG in improving cognitive function.
Main Methods:
- A randomized controlled trial involving 44 MCI patients.
- Patients were treated with either MWYG or Ginkgo leaf extract for 3 months.
- Key outcomes measured included memorial quotient (MQ), oxidative stress markers (SOD, MDA), mitochondrial DNA deletion rate, and acetylcholinesterase (AchE) activity.
Main Results:
- Both MWYG and Ginkgo leaf extract significantly improved MQ and serum SOD activity while decreasing serum MDA content, mtDNA deletion rate, and AchE activity (P < 0.01).
- No significant difference in efficacy was observed between the two treatment groups.
- No adverse reactions were reported in either group.
Conclusions:
- MWYG demonstrates comparable clinical efficacy to Ginkgo leaf extract in improving memorial function in MCI patients.
- The therapeutic mechanism may involve reducing AchE activity, enhancing free radical metabolism, and mitigating mitochondrial DNA oxidative damage.
- MWYG presents a safe and effective option for managing MCI.
