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Related Experiment Videos

Calcium-sensing receptor in the brain.

Shozo Yano1, Edward M Brown, Naibedya Chattopadhyay

  • 1Department of Medicine, Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA. syano@rics.bwh.harvard.edu

Cell Calcium
|June 18, 2004
PubMed
Summary

The calcium-sensing receptor (CaR) is found in many rat brain regions, including the subfornical organ and olfactory bulbs. This suggests CaR plays a role in regulating fluid balance and brain ionic homeostasis.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Physiology

Background:

  • The calcium-sensing receptor (CaR) regulates calcium homeostasis.
  • Its presence and function in the brain are not fully understood.

Purpose of the Study:

  • To localize the calcium-sensing receptor (CaR) in the adult and developing rat brain.
  • To investigate the potential roles of CaR in central fluid and electrolyte balance and brain ionic homeostasis.

Main Methods:

  • Cloning of the CaR using homology-based methods.
  • Immunocytochemistry with CaR-specific antibodies.
  • In situ hybridization with CaR-specific cDNA probes.

Main Results:

  • CaR expression was detected in numerous brain regions of adult and developing rats.

Related Experiment Videos

  • Highest CaR levels were found in the subfornical organ (SFO) and olfactory bulbs.
  • CaR was also expressed in the hippocampus, striatum, cerebellum, ependymal zones, perivascular nerves, and all three glial cell types.

    • Conclusions:

    • CaR in the SFO suggests a role in central fluid and electrolyte balance and thirst regulation.
    • Brain CaR expression indicates complex interactions between mineral ion homeostasis and neuroendocrine systems.
    • CaR in glial cells suggests roles in local ionic homeostasis and potential involvement in glioma.