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Updated: Aug 23, 2026

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion
Published on: April 19, 2024
Long-term outcomes after moderate to severe traumatic brain injury
A Colantonio1, G Ratcliff, S Chase
1Department of Occupational Therapy, University of Toronto, Ontario, Canada. angela.colantonio@utoronto.ca
Objective:
This research examined the long-term outcomes of rehabilitation patients with moderate to severe traumatic brain injury (TBI).
Design:
Retrospective cohort study.
Setting And Subjects:
We examined consecutive records of persons with moderate to severe traumatic brain injury who were discharged from a large rehabilitation hospital in Pennsylvania from 1973 to 1989. We interviewed consenting participants (n = 306) up to 24 years post-injury.
Main Outcome Measures:
Self-rated health, activity limitations, employment, living arrangements, marital status, Community Integration Questionnaire, and use of rehabilitation services.
Results:
Participants were most limited in activities such as managing money and shopping. Twenty-nine per cent of our participants were working full time. There were significant relationships between activity limitations and residual cognitive impairment at follow-up. Self-rated health was correlated with most instrumental activities of daily living.
Conclusion:
Our findings document health and function in a large post acute TBI population and implications for rehabilitation are discussed.
Related Concept Videos
Traumatic Brain Injury l: Introduction
Secondary Spinal Cord Injury llI: Pathophysiology

