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Updated: Aug 23, 2026

Synthesis of Zeolites Using the ADOR (Assembly-Disassembly-Organization-Reassembly) Route
Published on: April 3, 2016
Total synthesis of natural (+)-(2's,3'r)-zoapatanol
Catherine Taillier1, Véronique Bellosta, Janine Cossy
1Laboratoire de Chimie Organique, associé au CNRS, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Abstract:
[reaction: see text] (+)-Zoapatanol was synthesized by using four key-steps: a Suzuki cross-coupling to prepare a (Z)-alpha,beta-unsaturated ester followed by an enantioselective dihydroxylation to control the C2' and C3' stereocenters, an intramolecular Horner-Wadsworth-Emmons olefination to construct the oxepane ring, and a chemoselective nucleophilic addition/Birch reduction process of a Weinreb amide to introduce simultaneously the beta,gamma-unsaturated ketone on the side-chain and regenerate alcohols from benzyl ethers.
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