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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

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Transvascular lipoprotein transport in patients with chronic renal disease

Trine Krogsgaard Jensen1, Børge Grønne Nordestgaard, Bo Feldt-Rasmussen

  • 1Department of Nephrology and Endocrinology P, The National University Hospital, Copenhagen, Denmark.

Kidney International
|June 18, 2004
PubMed

Insights

Transvascular low-density lipoprotein (LDL) transport is altered in chronic renal disease, particularly in diabetic patients. This suggests increased lipoprotein flux into the arterial wall in diabetic individuals with kidney disease.

Area of Science:

  • Cardiovascular research
  • Nephrology
  • Lipid metabolism

Background:

  • Plasma cholesterol is a known cardiovascular risk factor in the general population, but its role in chronic renal disease (CRD) patients is less clear.
  • Hypothesized that transvascular lipoprotein transport, not just plasma concentration, influences atherosclerosis in CRD patients.

Purpose of the Study:

  • To investigate transvascular low-density lipoprotein (LDL) transport in patients with chronic renal disease (CRD) compared to healthy controls.
  • To determine if altered LDL transport contributes to atherosclerosis in CRD.

Main Methods:

  • Employed an in vivo method to measure transvascular LDL transport.
  • Utilized autologous 131-iodinated LDL reinjection and calculated the 1-hour fractional escape rate.
  • Studied 21 CRD patients and 42 healthy controls, including subgroups of diabetic and nondiabetic CRD patients.

Main Results:

  • Transvascular LDL transport showed a non-significant trend towards being lower in CRD patients than controls.
  • This trend disappeared when LDL transport was corrected for LDL distribution volume.
  • Significant variation in LDL transport was observed among diabetic CRD, nondiabetic CRD, and control groups (P < 0.01 after adjustment).

Conclusions:

  • Transvascular LDL transport may be elevated in diabetic CRD patients, indicating increased lipoprotein flux into the arterial wall.
  • This elevated flux mechanism does not appear to be present in nondiabetic CRD patients.
Abstract

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