Related Experiment Video
Updated: Apr 3, 2026

08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
13.8K
Trends in the ophthalmic literature, 1949-1989
1Department of Ophthalmology, University of Texas Medical Branch, Galveston 77550.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|September 1, 1992
Summary
Ophthalmic research shows a significant trend towards more authors, institutions, and collaborations. Financial support for studies has also markedly increased over five decades.
Area of Science:
- Ophthalmology
- Bibliometrics
- Scientific Publishing
Background:
- The Archives of Ophthalmology has published research for decades.
- Understanding trends in scientific literature is crucial for tracking research evolution.
Purpose of the Study:
- To analyze trends in ophthalmic literature over five decades.
- To identify changes in authorship, institutional collaboration, and funding.
Main Methods:
- Review of original articles from Archives of Ophthalmology.
- Data collection from publications in 1949, 1959, 1969, 1979, and 1989.
- Analysis of mean authors per article, mean institutions per article, and authors with Doctor of Philosophy (Ph.D.) degrees.
Main Results:
- Mean authors per article increased from 1.24 (1949) to 3.50 (1989).
- Mean institutions per article rose from 1.04 (1949) to 1.30 (1989).
- Proportion of articles with financial support increased from 13.5% (1949) to 62.6% (1989).
Conclusions:
- Ophthalmic literature demonstrates increasing collaboration among researchers.
- There is a growing trend of involving basic scientists (Ph.D. holders) in ophthalmic research.
- Grant funding has become a substantially larger component of ophthalmic research support.
Related Concept Videos
Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Ophthalmic Drug Delivery Systems
222
Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...
222

