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Updated: Aug 23, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
[Expression of hMSH2 gene in esophageal cancer]
Gong-yuan Zhang1, Qiu-liang Liu, Chun-xiao Ma
1Key Laboratory of Molecular Medicne, Zhengzhou University, Zhengzhou 450052, China. zgy@zzu.edu.cn
Objective:
To observe the expression of DNA mismatch repair gene hMSH2 mRNA in esophageal cancer tissues.
Methods:
This study included 32 esophageal cancer patients who received no previous radiotherapy, chemotherapy or other treatments. Within 30 min following surgical removal of the tumor tissues, specimens of the tumor, the tissue adjacent to the tumor and normal tissue at the esophageal stump (1 cmx1 cmx1 cm in size for each specimen) were obtained for examining hMSH2 expression with hMSH2 ISH detection kit.
Results:
The positivity rate of hMSH2 was 46.88% in the esophageal cancer tissues, 53.12% in the adjacent tissues, and 84.38% in normal tissues at the esophageal stump, showing significant difference of the former two tissues from the normal tissue (P<0.05). No significant correlation was noted between the positivity rate of hMSH2 and such factors as the patients' age, sex, tumor size, tumor location, pathological type, histological grade, lymphatic metastasis or degree of tumor invasion (P>0.05).
Conclusion:
The deletion of hMSH2 is an early event in the development of esophageal cancer.
Insights
DNA mismatch repair gene hMSH2 mRNA expression is significantly lower in esophageal cancer tissues and adjacent tissues compared to normal tissues. This suggests hMSH2 deletion is an early event in esophageal cancer development.
Area of Science:
- Molecular oncology
- Genetics of cancer
- DNA repair mechanisms
Context:
- Esophageal cancer is a significant global health concern.
- DNA mismatch repair (MMR) genes play a crucial role in maintaining genomic stability.
- Alterations in MMR genes, such as hMSH2, are implicated in various cancers.
Purpose:
- To investigate the expression levels of human MutS homolog 2 (hMSH2) mRNA in esophageal cancer tissues.
- To compare hMSH2 mRNA expression in tumor, adjacent, and normal esophageal tissues.
- To determine if hMSH2 expression correlates with clinicopathological features of esophageal cancer.
Summary:
- hMSH2 mRNA expression was analyzed in 32 treatment-naive esophageal cancer patients.
- Positivity rates for hMSH2 were significantly lower in tumor (46.88%) and adjacent (53.12%) tissues compared to normal tissues (84.38%).
- No correlation was found between hMSH2 expression and patient age, sex, tumor characteristics, or stage.
Impact:
- The findings indicate that reduced hMSH2 expression is an early event in esophageal carcinogenesis.
- This suggests a potential role for hMSH2 in esophageal cancer development and progression.
- Understanding hMSH2 alterations may inform future diagnostic or therapeutic strategies for esophageal cancer.
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