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Updated: Aug 23, 2026
Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
Published on: October 20, 2023
[Establishment of canine models of acute mesenteric ischamia]
Bo Yang1, Xian-yue Quan, Zhi-jian Yu
1Department of Radiology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. shybomb@163.com
Objective:
To establish a new canine model of acute mesenteric ischemia for imaging studies.
Methods:
Ten Beagle dogs were divided into ischemic group (n=8) and control group (n=2). Via a 4F Cobra catheter, the absolute ethanol was selectively injected into the superior mesenteric artery (SMA) for embolization in the former group while the saline was injected in the latter. Imaging study and pathological examination were performed.
Results:
Digital subtraction angiography (DSA) revealed that occlusion of some branches of the SMA was induced in the ischemic group while no changes occurred in the control group. The signs of acute mesenteric ischemia were confirmed by CT and pathological examination in the ischemic group whereas no abnormalities identified in the group.
Conclusion:
Canine models of acute mesenteric ischemia can be established by selective catheterization with absolute ethanol injection.
