Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myocardial tissue engineering: creating a muscle patch for a wounded heart.

Jonathan Leor1, Smadar Cohen

  • 1Neufeld Cardiac Research Institute, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer 52621, Israel. leorj@post.tau.ac.il

Annals of the New York Academy of Sciences
|June 18, 2004
PubMed
Summary

Cardiac tissue engineering offers a promising solution for heart failure by creating new heart tissue. This involves using cells on scaffolds to grow functional cardiac replacements, addressing donor shortages.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of Covalently Functionalized Alginate-Pyrrole and Polypyrrole-Alginate Nanocomposites as 3D Printable Electroconductive Bioinks.

Materials (Basel, Switzerland)·2025
Same author

Insights Into Heart-Tumor Interactions in Heart Failure.

Circulation research·2025
Same author

Atherosclerotic Cardiovascular Diseases Are Associated With Incident Metastatic and Nonmetastatic Cancer.

JACC. CardioOncology·2025
Same author

Response by Caller et al to Letter Regarding Article, "Small Extracellular Vesicles From Infarcted and Failing Heart Accelerate Tumor Growth".

Circulation·2024
Same author

Thermo-controlled microfluidic generation of monodisperse alginate microspheres based on external gelation.

RSC advances·2024
Same author

Terminal α1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions.

EMBO reports·2024

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • End-stage heart failure presents a critical unmet medical need.
  • The shortage of donor hearts limits treatment options.
  • Tissue engineering offers a potential solution for cardiac repair.

Purpose of the Study:

  • To provide an updated summary of cardiac tissue engineering research.
  • To highlight critical design principles in the field.
  • To explore the potential of engineered cardiac tissue for therapeutic applications.

Main Methods:

  • Review of current research studies in cardiac tissue engineering.
  • Analysis of cell sources, scaffold materials, and bioreactor technologies.
  • Evaluation of pre-clinical and clinical findings.

Related Experiment Videos

Main Results:

  • Cardiac tissue engineering utilizes donor cells and 3D scaffolds to create functional tissue.
  • Successful implantation can induce and direct the growth of new, healthy cardiac tissue.
  • Ongoing research focuses on optimizing scaffold design and cell integration.

Conclusions:

  • Cardiac tissue engineering holds significant promise for treating heart failure.
  • It offers a viable alternative to heart transplantation, addressing donor limitations.
  • Further research into critical design principles is essential for clinical translation.