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Related Experiment Videos

Persistent nicorandil induced oral ulceration.

C M Healy1, Y Smyth, S R Flint

  • 1Department of Oral Medicine, Dublin Dental Hospital, Lincoln Place, Dublin 2, Republic of Ireland. claire.healy@dental.tcd.ie

Heart (British Cardiac Society)
|June 18, 2004
PubMed
Summary

Nicorandil-induced ulcers are painful gastrointestinal issues often occurring at high doses. Reducing the nicorandil dose may heal these ulcers, but complete cessation might be necessary in severe cases.

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Pharmacology

Background:

  • Nicorandil is a medication used for angina.
  • Gastrointestinal ulceration is a known adverse effect of nicorandil.
  • Understanding the characteristics and management of these ulcers is crucial.

Observation:

  • Four cases of nicorandil-induced ulceration are presented.
  • These ulcers are characterized by significant pain, large size, depth, and punched-out edges.
  • Topical steroids show limited efficacy in treating these ulcers.

Findings:

  • Ulceration is often associated with high-dose nicorandil (≥40 mg/day).
  • Dose reduction can promote healing and prevent recurrence.
  • In some instances, even lower doses (10 mg/day) can trigger ulceration, necessitating complete drug cessation.

Implications:

  • Clinicians should be vigilant for nicorandil-induced ulcers in patients experiencing gastrointestinal distress.
  • Management strategies include dose adjustment or discontinuation of nicorandil.
  • Further research into the mechanisms and optimal treatment of nicorandil-induced ulcers is warranted.

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