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Risk factors for mortality in patients undergoing percutaneous endoscopic gastrostomy
1The Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, University of Tel-Aviv, Ramat-Gan, Israel. langa@sheba.health.gov.il
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Hospitalized patients face higher early mortality risks after percutaneous endoscopic gastrostomy (PEG) tube insertion compared to nursing home residents. Key risk factors include low albumin, COPD, and diabetes, significantly increasing 30-day mortality.
Area of Science:
- Gastroenterology
- Critical Care Medicine
- Geriatric Medicine
Background:
- Percutaneous endoscopic gastrostomy (PEG) is a vital feeding method for patients unable to eat.
- High early mortality rates have been observed in hospitalized patients undergoing PEG procedures.
- Identifying risk factors for early mortality post-PEG is crucial for patient management.
Purpose of the Study:
- To investigate and identify risk factors associated with early mortality following percutaneous endoscopic gastrostomy (PEG) tube insertion.
- To compare mortality rates between hospitalized patients and nursing home outpatients after PEG.
Main Methods:
- A comparative study analyzing data from 502 PEG insertions between July 1995 and July 2001.
- Survival analysis was employed to evaluate mortality post-PEG.
- Logistic regression identified predictors of 30-day mortality in hospitalized patients, including demographics, comorbidities, and PEG indications.
Main Results:
- Hospitalized patients exhibited significantly higher 30-day (8% vs. 1.2%) and 60-day (12% vs. 2.4%) mortality rates compared to nursing home patients.
- Low serum albumin (< 3 g/dl), chronic obstructive pulmonary disease (COPD), and diabetes mellitus were identified as independent risk factors for 30-day mortality in hospitalized patients.
- These risk factors increased 30-day mortality threefold in the hospitalized group.
Conclusions:
- Hospitalized patients undergoing PEG have a substantially elevated risk of early mortality compared to nursing home residents.
- Diabetes, COPD, and hypoalbuminemia are significant predictors of increased 30-day mortality post-PEG in hospitalized individuals.
- These findings underscore the need for careful patient selection and risk stratification prior to PEG insertion in hospitalized populations.
Background And Study Aims:
Percutaneous endoscopic gastrostomy (PEG) is a method used for feeding patients who are unable to eat. High early mortality rates among hospitalized patients have been reported. The aim of this study was to shed light on the risk factors for early mortality after PEG tube insertion.
Patients And Methods:
Outpatients from nursing homes and hospitalized patients who underwent PEG between July 1995 and July 2001 were compared. Survival analysis was used to assess mortality after PEG. In a logistic regression analysis, mortality within 30 days among hospitalized patients was chosen as the outcome variable and the predictor variables were demographic characteristics, co-morbid conditions, and indication for PEG.
Results:
A total of 502 PEG tubes were inserted in 419 hospitalized and 83 nursing-home patients. The prevalence of co-morbid conditions was similar in the two groups. Both the 30- and 60-day mortality rates were around six times higher in the hospitalized patient group than in the nursing-home patient group (30-day mortality rate 8 % vs. 1.2 %, P = 0.034; 60-day mortality rate 12 % vs. 2.4 %, P = 0.016). Risk factors for 30-day mortality among hospitalized patients were: serum albumin < 3 g/dl (odds ratio 2.82, 95 % CI 1.34 - 5.96), chronic obstructive pulmonary disease (odds ratio 2.79, 95 % CI 1.26 - 6.14), and diabetes mellitus (odds ratio 2.44, 95 % CI 1.20 - 4.97).
Conclusions:
Compared with nursing-home patients, hospitalized patients are at higher risk for early mortality after PEG. The presence of diabetes, chronic obstructive pulmonary disease, and a low serum albumin level each increase the 30-day mortality risk among hospitalized patients threefold.
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