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Related Experiment Videos

Castleman disease: a case with atypical presentation.

Nilgün Yaris1, Murat Cakir, Mukaddes Kalyoncu

  • 1Department of Paediatrics, Karadeniz Technical University, Faculty of Medicine, 61080 Trabzon, Turkey. nyaris@meds.ktu.edu.tr

Pediatric Hematology and Oncology
|June 19, 2004
PubMed
Summary
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Castleman disease, a rare lymph node disorder in children, typically presents localized and is cured by surgery. This case highlights a rare recurrence even after complete excision, presenting multically but without systemic symptoms.

Area of Science:

  • Pediatric Oncology
  • Hematology
  • Pathology

Background:

  • Castleman disease is a rare lymphoproliferative disorder.
  • It typically presents as localized, asymptomatic enlarged lymph nodes in children.
  • Surgical resection is usually curative for localized pediatric cases.

Observation:

  • A case of hyaline vascular-type Castleman disease diagnosed at one year of age is presented.
  • The disease recurred in the infraclavicular region despite complete excision of the primary site.
  • Post-recurrence, the disease became multicentric but remained asymptomatic.

Findings:

  • Recurrence of Castleman disease can occur even after complete surgical removal.
  • Multicentric Castleman disease may not always present with systemic symptoms in pediatric patients.

Related Experiment Videos

  • Hyaline vascular type Castleman disease, while typically benign, can exhibit aggressive behavior.

    • Implications:

    • This case underscores the importance of vigilant follow-up for pediatric Castleman disease patients.
    • It suggests that asymptomatic multicentric Castleman disease requires careful monitoring.
    • Further research into the behavior and management of recurrent pediatric Castleman disease is warranted.