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Related Experiment Videos

Soluble adhesion molecules in acute ischemic stroke.

Ana-Maria Simundic1, Vanja Basic, Elizabeta Topic

  • 1Clinical Institute of Chemistry, Department of Molecular Diagnostics, Sestre milosrdnice University Hospital, Zagreb, Croatia. ana-maria.simundic@post.hinet.hr

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|June 19, 2004
PubMed
Summary

Acute ischemic stroke is linked to higher levels of intercellular adhesion molecule-1 (sICAM-1), vascular cellular adhesion molecule-1 (sVCAM-1), and E-selectin. Lower levels of L-selectin are also associated with stroke.

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Area of Science:

  • Biochemistry
  • Immunology
  • Neurology

Background:

  • Inflammatory adhesion molecules are crucial in ischemic lesion development.
  • Plasma concentrations of soluble adhesion molecules in stroke patients show controversial data.
  • This study investigates the association of specific soluble adhesion molecules with acute ischemic stroke.

Purpose of the Study:

  • To explore the association of plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cellular adhesion molecule-1 (sVCAM-1), soluble E-selectin, and soluble L-selectin with acute ischemic stroke.

Main Methods:

  • Prospective enrollment of 67 acute ischemic stroke patients and 76 healthy controls.
  • Serum concentrations of sICAM-1, sVCAM-1, sE-selectin, and sL-selectin measured using quantitative sandwich enzyme immunoassay.

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  • Analysis of associations with demographic, clinical, and biochemical markers.

    • Main Results:

    • Mean levels of sICAM-1, sVCAM-1, and sE-selectin were significantly higher in stroke patients compared to controls.
    • Mean levels of sL-selectin were significantly lower in stroke patients.
    • sICAM-1, sVCAM-1, and sE-selectin levels were independent of age and sex, while sL-selectin showed inverse correlation with age and was higher in women and diabetics.
    • Concentrations of soluble adhesion molecules correlated with inflammatory markers like leukocyte count, ESR, and C-reactive protein.
    • sICAM-1, high-density lipoprotein-cholesterol, and ESR were identified as significant independent predictors of acute ischemic stroke.

    Conclusions:

    • Acute ischemic stroke is associated with elevated plasma levels of sICAM-1, sVCAM-1, and sE-selectin.
    • Decreased levels of sL-selectin are associated with acute stroke.
    • The observed changes in soluble adhesion molecule concentrations suggest an inflammatory process during acute cerebral ischemia.