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Synthesis and antiangiogenic activity of exo-olefinated deoxoartemisinin derivatives
Sangtae Oh1, In Howa Jeong, Woon-Seob Shin
1Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
Bioorganic & Medicinal Chemistry Letters
|June 19, 2004
Abstract:
10-exo-Bromoalkylidene and benzylidene deoxoartemisinin derivatives with antiangiogenic activity were synthesized from corresponding 10-alkanesulfonyl dihydroartemisinin and 10-phenylmethanesulfonyl dihydroartemisinin using a highly efficient, mild, and simple Ramberg-Bäcklund rearrangement.
