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Conformational feature of neuroactive domoic acid: X-ray structural comparison with isodomoic acid A and alpha-kainic
K Nomoto1, T Takemoto, M Maeda
1Suntory Institute for Bioorganic Research, Osaka, Japan.
Biochemical and Biophysical Research Communications
|August 31, 1992
Abstract:
As an aid for developing a new type of potent insecticide acting on the neuromuscular junction, conformational characteristics of domoic acid and isodomoic acid A, the naturally occurring glutamate agonists, were investigated by X-ray crystal analyses. Conformational comparison with a neuroactive alpha-kainic acid provides information concerning the stereochemical feature responsible for the biological activity.