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Updated: Aug 23, 2026
Detecting Migration and Infiltration of Neutrophils in Mice
Published on: February 6, 2020
Suppression of neutrophil recruitment in mice by geranium essential oil
Shigeru Abe1, Naho Maruyama, Kazumi Hayama
1Teikyo University Institute of Medical Mycology, Hachioji, Tokyo, Japan. sabe@main.teikyo-u.ac.jp
Background:
In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited.
Aims Of The Study:
To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo.
Method:
The effect of essential oils on leukocyte and neutrophil recruitment induced 6 h after intraperitoneal injection of casein in mice was examined.
Results:
Leukocyte recruitment into the peritoneal cavity in mice was suppressed by intraperitoneal injections of geranium, lemongrass and spearmint oils at the dose of 5 microl/mouse, but was not by tea tree oil. This recruitment was inhibited dose-dependently by geranium oil. The suppression of leukocyte recruitment resulted from inhibition of neutrophil accumulation.
Conclusion:
Some essential oils used as anti-inflammatory remedies suppress neutrophil recruitment into the peritoneal cavity in mice.
