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Monocyte chemoattractant protein-1 in patients with peripheral arterial disease

Jana Petrkova1, Jaroslava Szotkowska, Zuzana Hermanova

  • 1Department of Immunology, Palacky University and Faculty Hospital, Olomouc, Czech Republic.

Mediators of Inflammation
|June 19, 2004
PubMed

Insights

Monocyte chemoattractant protein-1 (MCP-1) is elevated in peripheral arterial disease (PAD) patients, suggesting its role in inflammation. MCP-1 levels may decrease with disease progression and correlate with lipid profiles.

Area of Science:

  • Cardiovascular Research
  • Immunology
  • Biochemistry

Background:

  • Inflammatory cell migration, driven by chemokines, contributes to atherosclerosis, including peripheral arterial disease (PAD).
  • Monocyte chemoattractant protein-1 (MCP-1) is a key chemokine implicated in inflammatory processes.
  • Elevated MCP-1 levels are observed in coronary artery disease and hypertension, prompting investigation in PAD.

Purpose of the Study:

  • To investigate the levels of Monocyte chemoattractant protein-1 (MCP-1) in patients with peripheral arterial disease (PAD).
  • To explore the relationship between MCP-1 levels and disease progression and risk factors in PAD.

Main Methods:

  • Serum MCP-1 was quantified using enzyme-linked immunosorbent assay (ELISA).
  • Study included 36 healthy controls and 19 patients diagnosed with PAD.
  • Statistical analysis involved Mann-Whitney and Spearman correlation tests.

Main Results:

  • MCP-1 levels were significantly higher in PAD patients (748 pg/ml) compared to controls (459 pg/ml) (p=0.0001).
  • MCP-1 levels showed a trend towards decrease with advancing disease severity.
  • Diabetes was associated with increased MCP-1, while hypertension had no significant effect. Serum MCP-1 correlated positively with cholesterol, triglycerides, and LDL, but not HDL.

Conclusions:

  • The elevated circulating MCP-1 in PAD patients supports its role in the inflammatory pathogenesis of the disease.
  • This pilot study suggests MCP-1 as a potential biomarker for monitoring peripheral arterial disease progression and prognosis.
  • Further research is warranted to validate MCP-1's utility in clinical follow-up of PAD.
Abstract

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