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Updated: Aug 23, 2026

Phospholipid Mediator Induced Transformation in Three-Dimensional Cultures
Published on: July 27, 2022
Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer
Yves Denizot1, Véronique Truffinet, Stéphane Bouvier
1Laboratoire d'immunologie, Faculté de Médecine, UMR CNRS 6101, 2 rue Dr. Marcland, Limoges, France. yves.denizot@unilim.fr
Abstract:
This clinical study reports that blood levels of the pro-inflammatory mediator platelet-activating factor (PAF) did not change in colorectal cancer patients. In contrast, plasma levels of two enzymatic activities, one implicated in PAF production (i.e. phospholipase A2) and one in PAF degradation (i.e. PAF acetylhydrolase activity) were significantly elevated.
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