Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Translational control in T lymphocytes.

Laura Beretta1

  • 1Department of Microbiology and Immunology, University of Michigan, Medical School, Ann Arbor, 48109-0620, USA. berettal@umich.edu

International Reviews of Immunology
|June 19, 2004
PubMed
Summary

Translational control regulates protein levels and T cell function. Dysregulation of this process, including translational infidelity, may drive systemic lupus erythematosus (SLE) and impact T cell proliferation and apoptosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developing a fully automated imaging biomarker for HCC risk assessment via MRI-based tumor segmentation and EPM.

Scientific reports·2026
Same author

Developing a Fully Automated Imaging Biomarker for HCC Risk Assessment via MRI-Based Tumor Segmentation and EPM.

medRxiv : the preprint server for health sciences·2025
Same author

Blood bacterial DNA signatures in a prospective cohort of patients with MASLD cirrhosis.

Hepatology communications·2025
Same author

Dimensionality Reduction and Nearest Neighbors for Improving Out-of-Distribution Detection in Medical Image Segmentation.

The journal of machine learning for biomedical imaging·2025
Same author

Correction for Kwan et al., "Gut phageome in Mexican Americans: a population at high risk for metabolic dysfunction-associated steatotic liver disease and diabetes".

mSystems·2024
Same author

Gut Microbiome and Hepatic Transcriptomic Determinants of HCC Development in Mice with Metabolic Dysfunction-Associated Steatohepatitis.

Journal of hepatocellular carcinoma·2024

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Translational control is a key mechanism regulating protein levels.
  • Both global and selective translational control influence cellular responses to stimuli.
  • Translational infidelity is implicated in T cell dysregulation in systemic lupus erythematosus (SLE).

Purpose of the Study:

  • To review current data on translational control in T cell biology.
  • To highlight the role of translational control in T cell signaling pathways.
  • To discuss the application of genomics for studying T cell gene expression.

Main Methods:

  • Literature review of translational control mechanisms.
  • Analysis of T cell signaling pathways.
  • Discussion of genomic analysis utility.

Main Results:

  • Translational control impacts T cell proliferation, apoptosis, and cytokine production.
  • Selective translational control affects genes involved in growth and apoptosis.
  • Genomic approaches can globally analyze translational control in T cells.

Conclusions:

  • Translational control is central to T cell biology and function.
  • Aberrant translational control, including infidelity, contributes to T cell dysregulation in SLE.
  • Further research using genomics can elucidate translational control mechanisms in T cells.

Related Experiment Videos