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Updated: Aug 17, 2026

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Reprogramming Mouse Embryonic Fibroblasts with Transcription Factors to Induce a Hemogenic Program
Published on: December 16, 2016
Pharmacological induction of fetal hemoglobin synthesis using histone deacetylase inhibitors
1Division of Medical Genetics, University of Washington, Seattle 98195, USA. huacao@u.washington.edu
Hematology (Amsterdam, Netherlands)
|June 19, 2004
Abstract:
A number of pharmacological agents are currently available for the induction of the fetal hemoglobin (Hb F) to treat the patients with sickle cell disease and beta-thalassemia. In the present review, we summarized the investigation and development of these Hb F-inducing agents and introduced histone deacetylase inhibitors as the new strategy to induce Hb F to treat the hemoglobin disorders

