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Gender difference in C-reactive protein concentrations in individuals with atherothrombotic risk factors and

Ori Rogowski1, David Zeltser, Itzhak Shapira

  • 1Department of Internal Medicine D Tel-Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239, Israel.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|June 19, 2004
PubMed

Insights

Gender differences in highly sensitive C-reactive protein (hs-CRP) exist, even when age and BMI are matched. These findings suggest current vascular risk stratification guidelines may need adjustment for hs-CRP cut-off points.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Inflammation Research

Background:

  • C-reactive proteins play a role in atherothrombosis.
  • hs-CRP concentrations may predict future vascular events.

Purpose of the Study:

  • To investigate gender disparities in highly sensitive C-reactive protein (hs-CRP) levels.
  • To compare hs-CRP in individuals with and without atherothrombotic risk factors.

Main Methods:

  • Matched cohort study of 469 females and 469 males.
  • Age and body mass index (BMI) were controlled for.
  • hs-CRP levels were measured in healthy individuals and those with risk factors.

Main Results:

  • Women exhibited higher hs-CRP concentrations than men in both healthy and overall cohorts (p<0.0005).
  • Significant gender differences persisted despite matching for age and BMI.

Conclusions:

  • Significant gender differences in hs-CRP levels are present, independent of age and BMI.
  • Clinical guidelines for vascular risk stratification using hs-CRP may require gender-specific cut-off points.

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