A registry-based study of gender, fetal growth, and risk of Wilms tumor

The possibility of an interaction between gender and fetal growth on the risk of Wilms tumor is poorly examined. Using nationwide population-based registries, the authors identified all children (N = 126) diagnosed with Wilms tumor in Denmark, 1973-1993, and selected 10 matched population controls per case. Data on birth weight, gestational age, and ponderal index were used to examine the association between gender, fetal growth, and risk of Wilms tumor. It was found that the risk of Wilms tumor increased with fetal growth in girls, but decreased with fetal growth in boys, although the findings did not reach statistical significance.