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Updated: Aug 23, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
Cribriform-morular variant of papillary thyroid carcinoma: ultrastructural study and somatic/germline mutation
Kaori Kameyama1, Makio Mukai, Hiroshi Takami
1Division of Diagnostic Pathology, Keio University School of Medicine, Tokyo, Japan. kameyama@sc.itc.keio.ac.jp
Abstract:
Cribriform-morular variant of papillary carcinoma is a distinctive histological variant of thyroid cancer, characterized by intermingled cribriform, follicular, papillary, trabecular, and morular architecture. These tumors are known to be associated with familial adenomatous polyposis (FAP), but are also encountered in non-FAP patients. The authors report on ultrastructural and genetic studies of 3 patients with this type of carcinoma-associated FAP. There were numerous microfilaments approximately 100 nm long at the nuclear clearing area of the morular regions. Two of the 3 patients showed germline APC mutations, and 1 had so somatic APC mutation. Both mutations were in previously unreported regions. The study provides new information for understanding the development of this rare tumor.
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