Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The Zimmerman-McLean-Foster hypothesis: 25 years later.

A D Singh1, I G Rennie, T Kivela

  • 1Department of Ophthalmic Oncology, Cole Eye Institute (i3-129), Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. arunsingh@eyetumors.com

The British Journal of Ophthalmology
|June 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unique case of a <i>GLI1</i> amplified biphasic mesenchymal tumor of the orbit.

Orbit (Amsterdam, Netherlands)·2023
Same author

Ecology of bats and their role in emerging zoonotic diseases: a review.

Revue scientifique et technique (International Office of Epizootics)·2022
Same author

Multi-drug resistant, biofilm-producing high-risk clonal lineage of Klebsiella in companion and household animals.

Letters in applied microbiology·2020
Same author

Diagnostic accuracy of FNAC and cyto-histopathological correlation in testicular and paratesticular mass lesions.

Cytopathology : official journal of the British Society for Clinical Cytology·2017
Same author

Fresh frozen amniotic membrane for conjunctival reconstruction after excision of neoplastic and presumed neoplastic conjunctival lesions.

Eye (London, England)·2017
Same author

Ultrastructural changes in the sublingual salivary gland of prenatal buffalo (Bubalus bubalis).

Veterinary world·2016
Same journal

Identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning.

The British journal of ophthalmology·2026
Same journal

Incidence of bilateral disease and choroidal neovascularisation in punctate inner choroiditis.

The British journal of ophthalmology·2026
Same journal

Reference map of multimodal vision deficits in intermediate age-related macular degeneration: contrast sensitivity and low-contrast visual acuity.

The British journal of ophthalmology·2026
Same journal

Commentary on 'identifying patients with poor visual outcomes after primary rhegmatogenous retinal detachment surgery using machine learning'.

The British journal of ophthalmology·2026
Same journal

Automated deep learning-based retinoschisis and detachment volume measurement in pathological myopia with posterior scleral contraction.

The British journal of ophthalmology·2026
Same journal

Bacterial keratitis: a global review of current practices, challenges and innovations.

The British journal of ophthalmology·2026
See all related articles

The Zimmerman-McLean-Foster hypothesis questioning enucleation for choroidal melanoma is re-evaluated. Current evidence suggests advances in uveal melanoma management and metastasis research support this hypothesis.

Area of Science:

  • Ophthalmology
  • Oncology
  • Cancer Metastasis Research

Background:

  • The 25-year-old Zimmerman-McLean-Foster article questioned enucleation for choroidal melanoma.
  • Enucleation was the standard treatment for uveal melanoma at that time.
  • Significant advancements have occurred in uveal melanoma management over 25 years.

Purpose of the Study:

  • To review the Zimmerman-McLean-Foster hypothesis.
  • To explore the hypothesis in light of current evidence.
  • To assess the evolution of uveal melanoma treatment and research.

Main Methods:

  • Review of clinical evidence.
  • Analysis of epidemiological data.
  • Examination of statistical findings.
  • Evaluation of experimental research in cancer metastasis.

Related Experiment Videos

Main Results:

  • The review synthesizes 25 years of research.
  • Pathobiology of cancer metastasis, particularly in uveal melanoma, has yielded new insights.
  • Clinical, epidemiological, and statistical data are considered.

Conclusions:

  • The Zimmerman-McLean-Foster hypothesis is critically examined against contemporary data.
  • The review provides an updated perspective on the management of uveal melanoma.
  • Insights into cancer metastasis inform the understanding of uveal melanoma treatment efficacy.