[The action of 5-fluorouracil in DMH-induced carcinogenesis in rats]

An experimental model to observe the action of 5-fluorouracil on rats with DMH-induced cancer of colon was designed. Ten Wistar rats were injected weekly with 25 subcutaneous doses (21 mg/kg) of DMH, and another ten, coinciding with the last 10 doses of the former, received intraperitoneally 10 mg/kg of the cytostatic agent. The animals were sacrificed 7 days after the last injection and samples of the colon processed by the "Swiss roll" technique. Differences in the weight of the animals and in the localization, size and macro and microscopic type of the tumours encountered, as well as the localization and grade of the dysplasias are studied.